WebJan 17, 2024 · Modify. 2024-02-04. Cell stimulation with viral ds RNA leads to the activation of two IKK-related serine/threonine kinases, TBK1 and IKK-i which directly phosphorylate IRF3 and IRF7 promoting their dimerization and translocation into the nucleus. Although both kinases show structural and functional similarities, it seems that TBK1 and IKK-i ... WebSep 19, 2013 · IRF3 is a constitutively expressed transcription factor that resides in the cytoplasm and dimerizes and translocates to the nucleus upon phosphorylation ( 6 ). Phosphorylated IRF3 induces IFN-β during viral infection, but may also contribute to inflammatory cytokine response to LPS ( 7 ).
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WebNov 20, 2024 · There are two identified AIDs in IRF3 located in the N- and C-terminal regions compared to one AID found in IRF5 and IRF7 ( 14, 101, 102 ). The IRF3 crystal structure in its latent (unstimulated or autoinhibited monomer) form revealed the hydrophobic surface and a region essential for CBP/p300 binding that is masked by the AID ( 14 ). WebApr 9, 2024 · The m6A demethylase ALKBH5 promotes tumor progression by inhibiting RIG-I expression and interferon alpha production through the IKKε/TBK1/IRF3 pathway in head and neck squamous cell carcinoma Molecular Cancer Full Text Research Open Access Published: 09 April 2024 greenfield highlands apartments
The STING-IRF3 pathway is involved in lipotoxic injury of …
WebApr 5, 2024 · This stimulates organization of cytosolic cGAS onto the mtDNA-CAP, and subsequent activation of the cGAS-STING-IRF3 pathway. TGF-β is unable to induce conversion of HSC from a quiescent to a trans-differentiated phenotype in the absence of mtDNA, VDAC or STING. Trans-differentiation by TGF-β is blocked by a STING inhibitor … WebFeb 17, 2024 · STING or IRF3 knockouts can then improve inflammation and apoptosis induced by PA and reverse impaired insulin synthesis. The STING-IRF3 pathway has also been shown to play an important role in pancreatic β-cell lipotoxicity. However, the role of the STING-IRF3 pathway in psoriasis with diabetes has not been reported. WebIRF3 is a transcription factor that controls multiple IFN-inducing pathways, including the TLR3 pathway, which can be triggered by dsRNA, and the pathways triggered by other … greenfield henry ford museum