WebThe new engl and journal of medicine 582 n engl j med 357;6 www.nejm.org august 9, 2007 penia after injection of iodinated contrast medi-um for radiographic studies.12,13 Whether immune mechanisms ... WebMechanism of Action. Phenytoin improves evidence of seizures by interfering with sodium channels in the brain, resulting in a reduction of sustained high-frequency neuronal discharges. ... These have included thrombocytopenia, leukopenia, granulocytopenia, agranulocytosis, and pancytopenia with or without bone marrow suppression. ...
Phenytoin Toxicity - StatPearls - NCBI Bookshelf
WebNov 30, 2024 · Thrombocytopenia associated with use of fiban-type platelet inhibitors seems to be caused by antibodies that recognize immunogenic conformational changes … WebThrombocytopenia is a platelet count of less than 150 × 10 3 per μL and can occur from decreased platelet production, increased destruction, splenic sequestration, or dilution or … michael hauge coaching
Phenytoin Seizure Prophylaxis Therapy Resulting in Severe ...
WebJan 30, 2024 · BACKGROUND Phenytoin is an antiepileptic drug that is usually prescribed as a prevention treatment for tonic-clonic seizures or partial seizures, and as a prophylaxis … WebThrombocytopenia following administration of phenytoin, dexamethasone and cimetidine: a case report and a potential mechanism Cimetidine and phenytoin are useful medications often used together in patients with seizure disorders secondary to brain masses or metabolic abnormalities. WebJan 15, 2024 · Mechanism of Action. Phenytoin is a voltage-gated, sodium channel blocker, stabilizing the inactive state of the sodium channel and prolonging the neuronal refractory period. Phenytoin acts on the sodium channels on both neuronal and cardiac tissue. In the central nervous system, it targets neurons with high-frequency activity (as observed in ... michael hatzius steffi und thorsten